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Inotersen Sodium

CHEMBL4297537 Phase 4 ได้รับการอนุมัติ Oligonucleotide
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
— g/mol
LogP
—
Phase
4

This sodium salt of inotersen is an antisense oligonucleotide therapy used to treat the polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). It works by binding to transthyretin (TTR) mRNA in the liver and blocking production of the misfolded TTR protein that deposits in nerves and causes progressive damage. It is given by weekly subcutaneous injection.

กลไกการออกฤทธิ์

Binds to complementary mRNA sequences through Watson-Crick base pairing, modulating gene expression by promoting mRNA degradation via RNase H or altering pre-mRNA splicing.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

กลไก

Binds to complementary mRNA sequences through Watson-Crick base pairing, modulating gene expression by promoting mRNA degradation via RNase H or altering pre-mRNA splicing.

HBD / HBA

- / -

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

คำถามที่พบบ่อย

This sodium salt of inotersen is an antisense oligonucleotide therapy used to treat the polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). It works by binding to transthyretin (TTR) mRNA in the liver and blocking production of the misfolded TTR protein that deposits in nerves and causes progressive damage. It is given by weekly subcutaneous injection.

Binds to complementary mRNA sequences through Watson-Crick base pairing, modulating gene expression by promoting mRNA degradation via RNase H or altering pre-mRNA splicing.

Yes, Inotersen Sodium is an approved drug. It has reached clinical phase 4. It is classified as a Oligonucleotide.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

  • ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4297537. Open-access bioactivity database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-02-27.

ข้อจำกัดความรับผิดชอบทางการแพทย์

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.