Pexidartinib

CHEMBL3813873 Phase 4 ได้รับการอนุมัติ Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

417.8 g/mol

LogP

4.5

Phase

4

A kinase inhibitor used to treat tenosynovial giant cell tumor, a rare and often debilitating condition causing benign but destructive tumors in the joint lining. It works by blocking a signaling pathway that drives the abnormal growth of these tumor cells.

น้ำหนักโมเลกุล

417.8000 g/mol

LogP

4.50

TPSA

66.50 Å²

Lipinski RO5

ผ่าน

ด้านการรักษา

Melanoma Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Rheumatoid Arthritis Lymphoma Breast Cancer Prostate Cancer Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

โครงสร้าง 2 มิติ

SVG PNG

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SMILES

FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1

InChI

InChI=1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29)

Molecular Formula

C20H15ClF3N5

HBD / HBA

2 / 7

พันธะที่หมุนได้

5

อะตอมหนัก

29

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

คำถามที่พบบ่อย

A kinase inhibitor used to treat tenosynovial giant cell tumor, a rare and often debilitating condition causing benign but destructive tumors in the joint lining. It works by blocking a signaling pathway that drives the abnormal growth of these tumor cells.

Yes, Pexidartinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3813873. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 25151352. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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โครงสร้าง

ข้อมูลด่วน

สูตร: C20H15ClF3N5
คำพ้องความหมาย: 1

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This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.