Pralidoxime

CHEMBL1420 Phase 4 ได้รับการอนุมัติ Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

137.2 g/mol

LogP

1.0

Phase

4

Pralidoxime is a pyridinium oxime that reactivates organophosphate-inhibited cholinesterase by forming an oxime-phosphonate complex with the phosphorylated enzyme, thereby restoring normal enzyme activity and reversing the cholinergic crisis. It is used in combination with atropine for the treatment of organophosphate pesticide and nerve agent poisoning.

น้ำหนักโมเลกุล

137.1600 g/mol

LogP

1.00

TPSA

36.50 Å²

Lipinski RO5

ผ่าน

Pharmacokinetics (PK)

Pharmacodynamics (PD)

โครงสร้าง 2 มิติ

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SMILES

C[n+]1ccccc1C=NO

InChI

InChI=1S/C7H8N2O/c1-9-5-3-2-4-7(9)6-8-10/h2-6H,1H3/p+1

Molecular Formula

C7H9N2O+

HBD / HBA

1 / 2

พันธะที่หมุนได้

1

อะตอมหนัก

10

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

คำถามที่พบบ่อย

Pralidoxime is a pyridinium oxime that reactivates organophosphate-inhibited cholinesterase by forming an oxime-phosphonate complex with the phosphorylated enzyme, thereby restoring normal enzyme activity and reversing the cholinergic crisis. It is used in combination with atropine for the treatment of organophosphate pesticide and nerve agent poisoning.

Yes, Pralidoxime is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1420. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 135398747. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Pralidoxime บน PillFYI

โครงสร้าง

ข้อมูลด่วน

สูตร: C7H9N2O+
คำพ้องความหมาย: 3

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This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.