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Pretomanid

CHEMBL227875 Phase 4 ได้รับการอนุมัติ Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
359.3 g/mol
LogP
2.8
Phase
4

Pretomanid is a nitroimidazooxazine antimycobacterial agent that is activated by the deazaflavin-dependent nitroreductase (Ddn) of Mycobacterium tuberculosis, producing reactive nitrogen and carbon-based radicals that inhibit mycolic acid biosynthesis and cause cell death under both aerobic and anaerobic conditions. It is used in combination with bedaquiline and linezolid for the treatment of extensively drug-resistant (XDR) and treatment-intolerant or non-responsive multidrug-resistant tuberculosis.

น้ำหนักโมเลกุล

359.2600 g/mol

LogP

2.80

TPSA

91.30 Ų

Lipinski RO5

ผ่าน

ด้านการรักษา

Type 2 Diabetes Tuberculosis

Pharmacokinetics (PK)

Pharmacodynamics (PD)

โครงสร้าง 2 มิติ

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
O=[N+]([O-])c1cn2c(n1)OC[C@@H](OCc1ccc(OC(F)(F)F)cc1)C2

                

                

                
                

                    
InChI

                    
InChI=1S/C14H12F3N3O5/c15-14(16,17)25-10-3-1-9(2-4-10)7-23-11-5-19-6-12(20(21)22)18-13(19)24-8-11/h1-4,6,11H,5,7-8H2/t11-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C14H12F3N3O5

                    

                    
                    

                        
HBD / HBA

                        
- / 9

                    

                    
                    

                        
พันธะที่หมุนได้

                        
4

                    

                    
                    
                    

                        
อะตอมหนัก

                        
25

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
คำถามที่พบบ่อย

                

                    
                    

                        
                        

                            
Pretomanid is a nitroimidazooxazine antimycobacterial agent that is activated by the deazaflavin-dependent nitroreductase (Ddn) of Mycobacterium tuberculosis, producing reactive nitrogen and carbon-based radicals that inhibit mycolic acid biosynthesis and cause cell death under both aerobic and anaerobic conditions. It is used in combination with bedaquiline and linezolid for the treatment of extensively drug-resistant (XDR) and treatment-intolerant or non-responsive multidrug-resistant tuberculosis.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Pretomanid is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL227875.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 456199.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
ข้อจำกัดความรับผิดชอบทางการแพทย์

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.