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Spesolimab

CHEMBL4297911 Phase 4 ได้รับการอนุมัติ Antibody
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
— g/mol
LogP
—
Phase
4

Spesolimab is a humanized monoclonal antibody that blocks the interleukin-36 receptor (IL-36R), preventing signaling by the pro-inflammatory cytokines IL-36α, IL-36β, and IL-36γ, which drive keratinocyte-mediated inflammation in generalized pustular psoriasis (GPP). By inhibiting IL-36 receptor signaling, it rapidly suppresses the acute inflammatory cascade causing sterile pustule formation and systemic inflammation in GPP flares. It is approved for the treatment of GPP in adults and has orphan drug status for this rare condition.

ด้านการรักษา

Psoriasis

กลไกการออกฤทธิ์

As a monoclonal antibody, it binds with high specificity to its target antigen, modulating the immune response through mechanisms including receptor blockade, immune cell engagement, or targeted cytotoxicity.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

กลไก

As a monoclonal antibody, it binds with high specificity to its target antigen, modulating the immune response through mechanisms including receptor blockade, immune cell engagement, or targeted cytotoxicity.

HBD / HBA

- / -

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

คำถามที่พบบ่อย

Spesolimab is a humanized monoclonal antibody that blocks the interleukin-36 receptor (IL-36R), preventing signaling by the pro-inflammatory cytokines IL-36α, IL-36β, and IL-36γ, which drive keratinocyte-mediated inflammation in generalized pustular psoriasis (GPP). By inhibiting IL-36 receptor signaling, it rapidly suppresses the acute inflammatory cascade causing sterile pustule formation and systemic inflammation in GPP flares. It is approved for the treatment of GPP in adults and has orphan drug status for this rare condition.

As a monoclonal antibody, it binds with high specificity to its target antigen, modulating the immune response through mechanisms including receptor blockade, immune cell engagement, or targeted cytotoxicity.

Yes, Spesolimab is an approved drug. It has reached clinical phase 4. It is classified as a Antibody.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

  • ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4297911. Open-access bioactivity database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-02-27.

ข้อจำกัดความรับผิดชอบทางการแพทย์

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.