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Tazarotene

CHEMBL1657 Phase 4 ได้รับการอนุมัติ Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
351.5 g/mol
LogP
4.9
Phase
4

Tazarotene is a synthetic acetylenic retinoid that selectively binds to retinoic acid receptors RARβ and RARγ, modulating gene expression to normalize keratinocyte proliferation and differentiation. It is used topically for plaque psoriasis, acne vulgaris, and photoaging, and is under investigation for certain skin cancers and as part of combination regimens for bladder and breast cancers. Its receptor selectivity aims to provide efficacy while minimizing systemic retinoid-associated adverse effects.

น้ำหนักโมเลกุล

351.5000 g/mol

LogP

4.90

TPSA

64.50 Ų

Lipinski RO5

ผ่าน

ด้านการรักษา

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Psoriasis Systemic Lupus Erythematosus Lymphoma Breast Cancer Prostate Cancer Colorectal Cancer

กลไกการออกฤทธิ์

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

กลไก

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

โครงสร้าง 2 มิติ

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CCOC(=O)c1ccc(C#Cc2ccc3c(c2)C(C)(C)CCS3)nc1

                

                

                
                

                    
InChI

                    
InChI=1S/C21H21NO2S/c1-4-24-20(23)16-7-9-17(22-14-16)8-5-15-6-10-19-18(13-15)21(2,3)11-12-25-19/h6-7,9-10,13-14H,4,11-12H2,1-3H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C21H21NO2S

                    

                    
                    

                        
HBD / HBA

                        
- / 4

                    

                    
                    

                        
พันธะที่หมุนได้

                        
5

                    

                    
                    
                    

                        
อะตอมหนัก

                        
25

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
คำถามที่พบบ่อย

                

                    
                    

                        
                        

                            
Tazarotene is a synthetic acetylenic retinoid that selectively binds to retinoic acid receptors RARβ and RARγ, modulating gene expression to normalize keratinocyte proliferation and differentiation. It is used topically for plaque psoriasis, acne vulgaris, and photoaging, and is under investigation for certain skin cancers and as part of combination regimens for bladder and breast cancers. Its receptor selectivity aims to provide efficacy while minimizing systemic retinoid-associated adverse effects.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Tazarotene is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1657.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5381.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
ข้อจำกัดความรับผิดชอบทางการแพทย์

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.