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Teneligliptin

CHEMBL2147777 Phase 4 ได้รับการอนุมัติ Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
426.6 g/mol
LogP
2.4
Phase
4

Teneligliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor that prevents the degradation of incretin hormones GLP-1 and GIP, thereby enhancing glucose-dependent insulin secretion, suppressing glucagon release, and improving glycemic control in type 2 diabetes. Its unique thiazolidine-based structure provides prolonged DPP-4 inhibition and is approved in Japan, South Korea, and India for type 2 diabetes management. It may have additional cardiovascular benefits through reduction of myocardial remodeling, making it of interest in heart failure research.

น้ำหนักโมเลกุล

426.6000 g/mol

LogP

2.40

TPSA

81.90 Ų

Lipinski RO5

ผ่าน

ด้านการรักษา

Type 2 Diabetes Heart Failure

Pharmacokinetics (PK)

Pharmacodynamics (PD)

โครงสร้าง 2 มิติ

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
Cc1cc(N2CCN([C@@H]3CN[C@H](C(=O)N4CCSC4)C3)CC2)n(-c2ccccc2)n1

                

                

                
                

                    
InChI

                    
InChI=1S/C22H30N6OS/c1-17-13-21(28(24-17)18-5-3-2-4-6-18)26-9-7-25(8-10-26)19-14-20(23-15-19)22(29)27-11-12-30-16-27/h2-6,13,19-20,23H,7-12,14-16H2,1H3/t19-,20-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C22H30N6OS

                    

                    
                    

                        
HBD / HBA

                        
1 / 6

                    

                    
                    

                        
พันธะที่หมุนได้

                        
4

                    

                    
                    
                    

                        
อะตอมหนัก

                        
30

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
คำถามที่พบบ่อย

                

                    
                    

                        
                        

                            
Teneligliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor that prevents the degradation of incretin hormones GLP-1 and GIP, thereby enhancing glucose-dependent insulin secretion, suppressing glucagon release, and improving glycemic control in type 2 diabetes. Its unique thiazolidine-based structure provides prolonged DPP-4 inhibition and is approved in Japan, South Korea, and India for type 2 diabetes management. It may have additional cardiovascular benefits through reduction of myocardial remodeling, making it of interest in heart failure research.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Teneligliptin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL2147777.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 11949652.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
ข้อจำกัดความรับผิดชอบทางการแพทย์

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.