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Tirofiban

CHEMBL916 Phase 4 ได้รับการอนุมัติ Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
440.6 g/mol
LogP
1.4
Phase
4

Tirofiban is a non-peptide glycoprotein IIb/IIIa (αIIbβ3 integrin) receptor antagonist that blocks the binding of fibrinogen, von Willebrand factor, and other adhesive proteins to activated platelet receptors, preventing platelet aggregation and thrombus formation. It is used intravenously in combination with heparin for the management of acute coronary syndromes (unstable angina and NSTEMI) and percutaneous coronary intervention. Its reversible binding and short duration of action allow rapid recovery of platelet function after discontinuation.

น้ำหนักโมเลกุล

440.6000 g/mol

LogP

1.40

TPSA

113.00 Ų

Lipinski RO5

ผ่าน

ด้านการรักษา

Infectious Disease Respiratory Disease Chronic Obstructive Pulmonary Disease Alzheimer's Disease Parkinson's Disease Gastroesophageal Reflux Disease Inflammatory Bowel Disease Systemic Lupus Erythematosus Chronic Kidney Disease Non-Alcoholic Fatty Liver Disease Stroke Deep Vein Thrombosis / Pulmonary Embolism Cardiovascular Disease

กลไกการออกฤทธิ์

Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

กลไก

Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

โครงสร้าง 2 มิติ

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CCCCS(=O)(=O)N[C@@H](Cc1ccc(OCCCCC2CCNCC2)cc1)C(=O)O

                

                

                
                

                    
InChI

                    
InChI=1S/C22H36N2O5S/c1-2-3-16-30(27,28)24-21(22(25)26)17-19-7-9-20(10-8-19)29-15-5-4-6-18-11-13-23-14-12-18/h7-10,18,21,23-24H,2-6,11-17H2,1H3,(H,25,26)/t21-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C22H36N2O5S

                    

                    
                    

                        
HBD / HBA

                        
3 / 7

                    

                    
                    

                        
พันธะที่หมุนได้

                        
14

                    

                    
                    
                    

                        
อะตอมหนัก

                        
30

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
คำถามที่พบบ่อย

                

                    
                    

                        
                        

                            
Tirofiban is a non-peptide glycoprotein IIb/IIIa (αIIbβ3 integrin) receptor antagonist that blocks the binding of fibrinogen, von Willebrand factor, and other adhesive proteins to activated platelet receptors, preventing platelet aggregation and thrombus formation. It is used intravenously in combination with heparin for the management of acute coronary syndromes (unstable angina and NSTEMI) and percutaneous coronary intervention. Its reversible binding and short duration of action allow rapid recovery of platelet function after discontinuation.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Tirofiban is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL916.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 60947.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
ข้อจำกัดความรับผิดชอบทางการแพทย์

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.