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Tolazamide

CHEMBL817 Phase 4 ได้รับการอนุมัติ Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
311.4 g/mol
LogP
1.5
Phase
4

Tolazamide is a first-generation sulfonylurea that stimulates insulin secretion from pancreatic beta cells by binding to and blocking ATP-sensitive potassium channels (KATP), causing membrane depolarization, calcium influx, and insulin granule exocytosis. It is used as an oral antidiabetic agent for type 2 diabetes in patients where diet and exercise are insufficient, and has also been used in cardiovascular risk stratification studies. Its mechanism depends on functional beta cells and is ineffective in type 1 diabetes.

น้ำหนักโมเลกุล

311.4000 g/mol

LogP

1.50

TPSA

86.90 Ų

Lipinski RO5

ผ่าน

ด้านการรักษา

Type 2 Diabetes Cardiovascular Disease

Pharmacokinetics (PK)

Pharmacodynamics (PD)

โครงสร้าง 2 มิติ

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
Cc1ccc(S(=O)(=O)NC(=O)NN2CCCCCC2)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C14H21N3O3S/c1-12-6-8-13(9-7-12)21(19,20)16-14(18)15-17-10-4-2-3-5-11-17/h6-9H,2-5,10-11H2,1H3,(H2,15,16,18)

                

                

                

                    
                    

                        
Molecular Formula

                        
C14H21N3O3S

                    

                    
                    

                        
HBD / HBA

                        
2 / 4

                    

                    
                    

                        
พันธะที่หมุนได้

                        
3

                    

                    
                    
                    

                        
อะตอมหนัก

                        
21

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
คำถามที่พบบ่อย

                

                    
                    

                        
                        

                            
Tolazamide is a first-generation sulfonylurea that stimulates insulin secretion from pancreatic beta cells by binding to and blocking ATP-sensitive potassium channels (KATP), causing membrane depolarization, calcium influx, and insulin granule exocytosis. It is used as an oral antidiabetic agent for type 2 diabetes in patients where diet and exercise are insufficient, and has also been used in cardiovascular risk stratification studies. Its mechanism depends on functional beta cells and is ineffective in type 1 diabetes.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Tolazamide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL817.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5503.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
ข้อจำกัดความรับผิดชอบทางการแพทย์

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.