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Tromethamine

CHEMBL1200391 Phase 4 ได้รับการอนุมัติ Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
121.1 g/mol
LogP
-2.9
Phase
4

Tromethamine (TRIS) is an alkalinizing agent that buffers metabolic acidosis by accepting protons and increasing urinary pH, used in conditions such as cardiac surgery, respiratory acidosis, and metabolic acidosis. It is also used as a pharmaceutical excipient and as a salt-forming agent in drug formulations (e.g., ketorolac tromethamine) to enhance solubility. Its buffering capacity does not require carbon dioxide excretion, making it useful in patients with impaired ventilation.

น้ำหนักโมเลกุล

121.1400 g/mol

LogP

-2.90

TPSA

86.70 Ų

Lipinski RO5

ผ่าน

ด้านการรักษา

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Glaucoma Age-Related Macular Degeneration Pain Management Non-Small Cell Lung Cancer Migraine Generalized Anxiety Disorder Melanoma Deep Vein Thrombosis / Pulmonary Embolism Obesity Lymphoma Type 2 Diabetes Hypertension Breast Cancer Gout Chronic Pain Tuberculosis Prostate Cancer Colorectal Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

โครงสร้าง 2 มิติ

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
NC(CO)(CO)CO

                

                

                
                

                    
InChI

                    
InChI=1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2

                

                

                

                    
                    

                        
Molecular Formula

                        
C4H11NO3

                    

                    
                    

                        
HBD / HBA

                        
4 / 4

                    

                    
                    

                        
พันธะที่หมุนได้

                        
3

                    

                    
                    
                    

                        
อะตอมหนัก

                        
8

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
คำถามที่พบบ่อย

                

                    
                    

                        
                        

                            
Tromethamine (TRIS) is an alkalinizing agent that buffers metabolic acidosis by accepting protons and increasing urinary pH, used in conditions such as cardiac surgery, respiratory acidosis, and metabolic acidosis. It is also used as a pharmaceutical excipient and as a salt-forming agent in drug formulations (e.g., ketorolac tromethamine) to enhance solubility. Its buffering capacity does not require carbon dioxide excretion, making it useful in patients with impaired ventilation.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Tromethamine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1200391.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 6503.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
ข้อจำกัดความรับผิดชอบทางการแพทย์

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.