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Vismodegib

CHEMBL473417 Phase 4 ได้รับการอนุมัติ Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
421.3 g/mol
LogP
3.8
Phase
4

This targeted therapy blocks the Hedgehog signaling pathway, which is abnormally activated in most basal cell carcinomas, and is used to treat locally advanced or metastatic basal cell carcinoma (a type of skin cancer) that cannot be treated with surgery or radiation. It is taken as a daily oral capsule. It causes severe birth defects and is absolutely contraindicated during pregnancy; severe muscle spasms and hair loss are also very common side effects.

น้ำหนักโมเลกุล

421.3000 g/mol

LogP

3.80

TPSA

84.50 Ų

Lipinski RO5

ผ่าน

ด้านการรักษา

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Melanoma Lymphoma Breast Cancer Prostate Cancer Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

โครงสร้าง 2 มิติ

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CS(=O)(=O)c1ccc(C(=O)Nc2ccc(Cl)c(-c3ccccn3)c2)c(Cl)c1

                

                

                
                

                    
InChI

                    
InChI=1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24)

                

                

                

                    
                    

                        
Molecular Formula

                        
C19H14Cl2N2O3S

                    

                    
                    

                        
HBD / HBA

                        
1 / 4

                    

                    
                    

                        
พันธะที่หมุนได้

                        
4

                    

                    
                    
                    

                        
อะตอมหนัก

                        
27

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
คำถามที่พบบ่อย

                

                    
                    

                        
                        

                            
This targeted therapy blocks the Hedgehog signaling pathway, which is abnormally activated in most basal cell carcinomas, and is used to treat locally advanced or metastatic basal cell carcinoma (a type of skin cancer) that cannot be treated with surgery or radiation. It is taken as a daily oral capsule. It causes severe birth defects and is absolutely contraindicated during pregnancy; severe muscle spasms and hair loss are also very common side effects.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Vismodegib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL473417.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 24776445.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
ข้อจำกัดความรับผิดชอบทางการแพทย์

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.