คำอธิบาย
Low-dose aspirin combined with dabigatran increases bleeding risk; clinical evidence suggests a 2-fold increase in major bleeding events.
กลไก
Aspirin irreversibly inhibits platelet COX-1, reducing thromboxane A2 and impairing primary hemostasis; dabigatran inhibits secondary hemostasis by blocking thrombin.
ความสำคัญทางคลินิก
The RE-LY trial showed substantially higher bleeding rates when aspirin was combined with dabigatran versus dabigatran alone.
การจัดการ
Use combination only when there is a clear indication; monitor closely; add PPI; use lowest effective aspirin dose.
ข้อจำกัดความรับผิดชอบทางการแพทย์
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.