คำอธิบาย
Aspirin reduces methotrexate clearance by competing for renal tubular secretion, raising plasma methotrexate levels and toxicity risk.
กลไก
Salicylates compete with methotrexate for organic anion transporter-mediated renal excretion; they may also displace methotrexate from plasma proteins, transiently increasing free drug concentrations.
ความสำคัญทางคลินิก
Methotrexate toxicity (bone marrow suppression, mucositis, nephrotoxicity) has been reported when NSAIDs/aspirin are added; high-dose MTX regimens carry the greatest risk.
การจัดการ
Avoid combination with high-dose MTX; monitor CBC and renal function with low-dose rheumatology regimens; withhold aspirin for 48 h around weekly MTX dose.
ข้อจำกัดความรับผิดชอบทางการแพทย์
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.