คำอธิบาย
Both azithromycin and hydroxychloroquine independently prolong the cardiac QT interval; concurrent use substantially raises the risk of torsades de pointes and sudden cardiac death.
กลไก
Both drugs block cardiac hERG (IKr) potassium channels, prolonging ventricular repolarization in an additive or supra-additive manner.
ความสำคัญทางคลินิก
This combination received global attention during the COVID-19 pandemic when pharmacovigilance data showed excess arrhythmia-related deaths.
การจัดการ
Avoid concurrent use; obtain baseline and follow-up ECG if co-prescription is unavoidable, correct electrolytes, and avoid other QT-prolonging drugs.
ข้อจำกัดความรับผิดชอบทางการแพทย์
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.