Acyclovir vs Trimethoprim

## Acyclovir vs Trimethoprim: Overview

This comparison examines the pharmacological differences between **Acyclovir** and **Trimethoprim**.

## Mechanism of Action

**Acyclovir**: Guanosine analogue inhibiting viral DNA polymerase.

**Trimethoprim**: Dihydrofolate reductase inhibitor (bacterial selective).

## Pharmacokinetics

**Half-life**: Acyclovir — 2.5-3.3 hours; Trimethoprim — 8-10 hours.

## Chemical Properties

**Molecular Formula**: Acyclovir — C8H11N5O3; Trimethoprim — C14H18N4O3.

**Molecular Weight**: Acyclovir — 225.2050 g/mol; Trimethoprim — 290.3180 g/mol.

**Type**: Acyclovir — Small molecule; Trimethoprim — Small molecule.