Allopurinol vs Methotrexate

## Allopurinol vs Methotrexate: Overview

This comparison examines the pharmacological differences between **Allopurinol** and **Methotrexate**.

## Mechanism of Action

**Allopurinol**: Xanthine oxidase inhibitor reducing uric acid production.

**Methotrexate**: Dihydrofolate reductase inhibitor.

## Pharmacokinetics

**Half-life**: Allopurinol — 1-2 hours; Methotrexate — 3-10 hours.

## Chemical Properties

**Molecular Formula**: Allopurinol — C5H4N4O; Methotrexate — C20H22N8O5.

**Molecular Weight**: Allopurinol — 136.1120 g/mol; Methotrexate — 454.4400 g/mol.

**Type**: Allopurinol — Small molecule; Methotrexate — Small molecule.