Levofloxacin vs Trimethoprim

## Levofloxacin vs Trimethoprim: Overview

This comparison examines the pharmacological differences between **Levofloxacin** and **Trimethoprim**.

## Mechanism of Action

**Levofloxacin**: Fluoroquinolone antibiotic inhibiting bacterial DNA gyrase and topoisomerase IV.

**Trimethoprim**: Dihydrofolate reductase inhibitor (bacterial selective).

## Pharmacokinetics

**Half-life**: Levofloxacin — 6-8 hours; Trimethoprim — 8-10 hours.

## Chemical Properties

**Molecular Formula**: Levofloxacin — C18H20FN3O4; Trimethoprim — C14H18N4O3.

**Molecular Weight**: Levofloxacin — 361.3680 g/mol; Trimethoprim — 290.3180 g/mol.

**Type**: Levofloxacin — Small molecule; Trimethoprim — Small molecule.