Abrocitinib
An oral medication that works inside immune cells by blocking a signaling enzyme called JAK1, reducing the inflammatory signals that drive itching and skin inflammation in eczema. It is approved for moderate-to-severe atopic dermatitis in adults and adolescents when other treatments have not worked well enough. Patients should avoid live vaccines while taking it and should be aware of a small increased risk of serious infections, blood clots, and cardiovascular events.
Moleküler Ağırlık
323,4200 g/mol
LogP
1,70
TPSA
99,40 Ų
Lipinski RO5
Geçer
Terapötik Alanlar
Etki Mekanizması
Stimulates the adaptive immune system to produce antigen-specific antibodies and memory cells, providing protective immunity against subsequent exposure to the pathogen.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Stimulates the adaptive immune system to produce antigen-specific antibodies and memory cells, providing protective immunity against subsequent exposure to the pathogen.
2D Yapı
Cite this structure
Embed this structure
SMILES
CCCS(=O)(=O)N[C@H]1C[C@@H](N(C)c2ncnc3[nH]ccc23)C1
InChI
InChI=1S/C14H21N5O2S/c1-3-6-22(20,21)18-10-7-11(8-10)19(2)14-12-4-5-15-13(12)16-9-17-14/h4-5,9-11,18H,3,6-8H2,1-2H3,(H,15,16,17)/t10-,11+
Molecular Formula
C14H21N5O2S
HBD / HBA
2 / 6
Döndürülebilir Bağlar
6
Ağır Atomlar
22
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Sıkça Sorulan Sorular
An oral medication that works inside immune cells by blocking a signaling enzyme called JAK1, reducing the inflammatory signals that drive itching and skin inflammation in eczema. It is approved for moderate-to-severe atopic dermatitis in adults and adolescents when other treatments have not worked well enough. Patients should avoid live vaccines while taking it and should be aware of a small increased risk of serious infections, blood clots, and cardiovascular events.
Stimulates the adaptive immune system to produce antigen-specific antibodies and memory cells, providing protective immunity against subsequent exposure to the pathogen.
Yes, Abrocitinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3655081. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 78323835. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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