Antazoline Phosphate
The phosphate salt of antazoline, commonly formulated in ophthalmic drops to reduce eye allergy symptoms by blocking histamine receptors locally. It is often combined with a decongestant for more complete symptom relief.
Moleküler Ağırlık
363,3000 g/mol
TPSA
105,00 Ų
Terapötik Alanlar
Etki Mekanizması
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
2D Yapı
Cite this structure
Embed this structure
SMILES
O=P(O)(O)O.c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1
InChI
InChI=1S/C17H19N3.H3O4P/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16;1-5(2,3)4/h1-10H,11-14H2,(H,18,19);(H3,1,2,3,4)
Molecular Formula
C17H22N3O4P
HBD / HBA
4 / 6
Döndürülebilir Bağlar
5
Ağır Atomlar
25
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Sıkça Sorulan Sorular
The phosphate salt of antazoline, commonly formulated in ophthalmic drops to reduce eye allergy symptoms by blocking histamine receptors locally. It is often combined with a decongestant for more complete symptom relief.
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Yes, Antazoline Phosphate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200550. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 158798. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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