Aprepitant
A substance P/neurokinin-1 receptor antagonist that blocks signals in the brain that trigger nausea and vomiting, commonly used to prevent chemotherapy-induced and postoperative nausea. It is often combined with other antiemetic drugs for maximum effectiveness.
Moleküler Ağırlık
534,4000 g/mol
LogP
4,20
TPSA
75,20 Ų
Lipinski RO5
Başarısız
Terapötik Alanlar
Etki Mekanizması
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
2D Yapı
Cite this structure
Embed this structure
SMILES
C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1
InChI
InChI=1S/C23H21F7N4O3/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)37-20-19(13-2-4-17(24)5-3-13)34(6-7-36-20)11-18-31-21(35)33-32-18/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H2,31,32,33,35)/t12-,19+,20-/m1/s1
Molecular Formula
C23H21F7N4O3
HBD / HBA
2 / 12
Döndürülebilir Bağlar
6
Ağır Atomlar
37
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Sıkça Sorulan Sorular
A substance P/neurokinin-1 receptor antagonist that blocks signals in the brain that trigger nausea and vomiting, commonly used to prevent chemotherapy-induced and postoperative nausea. It is often combined with other antiemetic drugs for maximum effectiveness.
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Yes, Aprepitant is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1471. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 135413536. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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