Carbenicillin Indanyl
An oral ester prodrug of carbenicillin that is absorbed from the gut and then hydrolyzed to release active carbenicillin. It was used to treat urinary tract infections caused by susceptible organisms, particularly Pseudomonas. Its use is largely historical, replaced by fluoroquinolones and other oral agents with better systemic activity.
Moleküler Ağırlık
494,6000 g/mol
LogP
3,80
TPSA
138,00 Ų
Lipinski RO5
Geçer
Etki Mekanizması
Inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. This leads to breakage of bacterial chromosomal DNA and rapid cell death.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. This leads to breakage of bacterial chromosomal DNA and rapid cell death.
2D Yapı
Cite this structure
Embed this structure
SMILES
CC1(C)S[C@@H]2[C@H](NC(=O)C(C(=O)Oc3ccc4c(c3)CCC4)c3ccccc3)C(=O)N2[C@H]1C(=O)O
InChI
InChI=1S/C26H26N2O6S/c1-26(2)20(24(31)32)28-22(30)19(23(28)35-26)27-21(29)18(15-7-4-3-5-8-15)25(33)34-17-12-11-14-9-6-10-16(14)13-17/h3-5,7-8,11-13,18-20,23H,6,9-10H2,1-2H3,(H,27,29)(H,31,32)/t18?,19-,20+,23-/m1/s1
Molecular Formula
C26H26N2O6S
HBD / HBA
2 / 7
Döndürülebilir Bağlar
7
Ağır Atomlar
35
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Sıkça Sorulan Sorular
An oral ester prodrug of carbenicillin that is absorbed from the gut and then hydrolyzed to release active carbenicillin. It was used to treat urinary tract infections caused by susceptible organisms, particularly Pseudomonas. Its use is largely historical, replaced by fluoroquinolones and other oral agents with better systemic activity.
Inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. This leads to breakage of bacterial chromosomal DNA and rapid cell death.
Yes, Carbenicillin Indanyl is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1596. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 93184. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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