Chlorothiazide
The first thiazide diuretic developed, working by inhibiting sodium and chloride reabsorption in the distal tubule of the kidney to promote urine output and lower blood pressure. It is used to treat hypertension and edema associated with heart failure, renal disease, and cirrhosis. Metabolic side effects include hypokalemia, hyperglycemia, and elevated uric acid levels.
Moleküler Ağırlık
295,7000 g/mol
LogP
-0,20
TPSA
135,00 Ų
Lipinski RO5
Geçer
Terapötik Alanlar
Etki Mekanizması
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.
2D Yapı
Cite this structure
Embed this structure
SMILES
NS(=O)(=O)c1cc2c(cc1Cl)N=CNS2(=O)=O
InChI
InChI=1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)
Molecular Formula
C7H6ClN3O4S2
HBD / HBA
2 / 6
Döndürülebilir Bağlar
1
Ağır Atomlar
17
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Sıkça Sorulan Sorular
The first thiazide diuretic developed, working by inhibiting sodium and chloride reabsorption in the distal tubule of the kidney to promote urine output and lower blood pressure. It is used to treat hypertension and edema associated with heart failure, renal disease, and cirrhosis. Metabolic side effects include hypokalemia, hyperglycemia, and elevated uric acid levels.
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.
Yes, Chlorothiazide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL842. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2720. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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