Dantrolene Sodium
The sodium salt form of dantrolene used as an injectable for malignant hyperthermia emergencies and orally for chronic spasticity from conditions such as multiple sclerosis or cerebral palsy. It reduces muscle tone by directly blocking calcium-mediated contraction.
Moleküler Ağırlık
336,2300 g/mol
TPSA
127,00 Ų
Terapötik Alanlar
Etki Mekanizması
Reduces skeletal muscle tone and spasm through central or peripheral mechanisms, typically by modulating spinal reflexes, enhancing inhibitory neurotransmission, or blocking neuromuscular transmission.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Reduces skeletal muscle tone and spasm through central or peripheral mechanisms, typically by modulating spinal reflexes, enhancing inhibitory neurotransmission, or blocking neuromuscular transmission.
2D Yapı
Cite this structure
Embed this structure
SMILES
O=C1CN(/N=C/c2ccc(-c3ccc([N+](=O)[O-])cc3)o2)C(=O)[N-]1.[Na+]
InChI
InChI=1S/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;/h1-7H,8H2,(H,16,19,20);/q;+1/p-1/b15-7+;
Molecular Formula
C14H9N4NaO5
HBD / HBA
- / 6
Döndürülebilir Bağlar
3
Ağır Atomlar
24
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Sıkça Sorulan Sorular
The sodium salt form of dantrolene used as an injectable for malignant hyperthermia emergencies and orally for chronic spasticity from conditions such as multiple sclerosis or cerebral palsy. It reduces muscle tone by directly blocking calcium-mediated contraction.
Reduces skeletal muscle tone and spasm through central or peripheral mechanisms, typically by modulating spinal reflexes, enhancing inhibitory neurotransmission, or blocking neuromuscular transmission.
Yes, Dantrolene Sodium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL928. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6604100. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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