Leniolisib

CHEMBL3643413 Phase 4 Onaylandı Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

450.5 g/mol

LogP

2.5

Phase

4

A PI3K-delta inhibitor being investigated for the treatment of activated PI3K delta syndrome (APDS), a rare primary immunodeficiency disorder. It works by blocking a specific enzyme involved in abnormal B and T cell signaling.

Moleküler Ağırlık

450,5000 g/mol

LogP

2,50

TPSA

83,50 Å²

Lipinski RO5

Geçer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Yapı

SVG PNG

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SMILES

CCC(=O)N1CC[C@H](Nc2ncnc3c2CN(c2cnc(OC)c(C(F)(F)F)c2)CC3)C1

InChI

InChI=1S/C21H25F3N6O2/c1-3-18(31)30-6-4-13(10-30)28-19-15-11-29(7-5-17(15)26-12-27-19)14-8-16(21(22,23)24)20(32-2)25-9-14/h8-9,12-13H,3-7,10-11H2,1-2H3,(H,26,27,28)/t13-/m0/s1

Molecular Formula

C21H25F3N6O2

HBD / HBA

1 / 10

Döndürülebilir Bağlar

5

Ağır Atomlar

32

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Sıkça Sorulan Sorular

A PI3K-delta inhibitor being investigated for the treatment of activated PI3K delta syndrome (APDS), a rare primary immunodeficiency disorder. It works by blocking a specific enzyme involved in abnormal B and T cell signaling.

Yes, Leniolisib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3643413. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 57495353. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Hızlı Veriler

Formül: C21H25F3N6O2
Eş Anlamlılar: 1

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Tıbbi Sorumluluk Reddi

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.