Meclizine
An antihistamine used to prevent and treat nausea, vomiting, and dizziness associated with motion sickness and inner ear disorders such as vertigo. It works by blocking histamine and muscarinic receptors in the brain's vomiting center.
Moleküler Ağırlık
390,9000 g/mol
LogP
5,80
TPSA
6,50 Ų
Lipinski RO5
Geçer
Etki Mekanizması
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
2D Yapı
Cite this structure
Embed this structure
SMILES
Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1
InChI
InChI=1S/C25H27ClN2/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23/h2-13,18,25H,14-17,19H2,1H3
Molecular Formula
C25H27ClN2
HBD / HBA
- / 2
Döndürülebilir Bağlar
5
Ağır Atomlar
28
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Sıkça Sorulan Sorular
An antihistamine used to prevent and treat nausea, vomiting, and dizziness associated with motion sickness and inner ear disorders such as vertigo. It works by blocking histamine and muscarinic receptors in the brain's vomiting center.
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Yes, Meclizine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1623. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 4034. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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