Pholcodine
Pholcodine is an opioid cough suppressant (antitussive) structurally related to codeine that acts on mu-opioid receptors in the medullary cough center to suppress the cough reflex. It is used for the symptomatic relief of dry, non-productive cough, and unlike codeine, has minimal analgesic activity and lower abuse potential, though it has been associated with sensitization to neuromuscular blocking agents.
Moleküler Ağırlık
398,5000 g/mol
LogP
0,80
TPSA
54,40 Ų
Lipinski RO5
Geçer
Etki Mekanizması
Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.
2D Yapı
Cite this structure
Embed this structure
SMILES
CN1CC[C@]23c4c5ccc(OCCN6CCOCC6)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5
InChI
InChI=1S/C23H30N2O4/c1-24-7-6-23-16-3-4-18(26)22(23)29-21-19(5-2-15(20(21)23)14-17(16)24)28-13-10-25-8-11-27-12-9-25/h2-5,16-18,22,26H,6-14H2,1H3/t16-,17+,18-,22-,23-/m0/s1
Molecular Formula
C23H30N2O4
HBD / HBA
1 / 6
Döndürülebilir Bağlar
4
Ağır Atomlar
29
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Sıkça Sorulan Sorular
Pholcodine is an opioid cough suppressant (antitussive) structurally related to codeine that acts on mu-opioid receptors in the medullary cough center to suppress the cough reflex. It is used for the symptomatic relief of dry, non-productive cough, and unlike codeine, has minimal analgesic activity and lower abuse potential, though it has been associated with sensitization to neuromuscular blocking agents.
Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.
Yes, Pholcodine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2105224. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5311356. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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