Rimegepant
A CGRP receptor antagonist used both to treat acute migraine attacks and as a preventive therapy taken every other day. It works by blocking the calcitonin gene-related peptide receptor involved in migraine pain signaling, offering relief without the cardiovascular risks associated with triptans.
Moleküler Ağırlık
534,6000 g/mol
LogP
2,30
TPSA
114,00 Ų
Lipinski RO5
Geçer
Terapötik Alanlar
Etki Mekanizması
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
2D Yapı
Cite this structure
Embed this structure
SMILES
N[C@@H]1c2cccnc2[C@H](OC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)CC[C@H]1c1cccc(F)c1F
InChI
InChI=1S/C28H28F2N6O3/c29-20-6-1-4-17(23(20)30)18-8-9-22(25-19(24(18)31)5-2-12-32-25)39-28(38)35-14-10-16(11-15-35)36-21-7-3-13-33-26(21)34-27(36)37/h1-7,12-13,16,18,22,24H,8-11,14-15,31H2,(H,33,34,37)/t18-,22+,24-/m0/s1
Molecular Formula
C28H28F2N6O3
HBD / HBA
2 / 8
Döndürülebilir Bağlar
4
Ağır Atomlar
39
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Sıkça Sorulan Sorular
A CGRP receptor antagonist used both to treat acute migraine attacks and as a preventive therapy taken every other day. It works by blocking the calcitonin gene-related peptide receptor involved in migraine pain signaling, offering relief without the cardiovascular risks associated with triptans.
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Yes, Rimegepant is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2178422. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 51049968. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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