Sacubitril

CHEMBL3137301 Phase 4 Onaylandı Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

411.5 g/mol

LogP

3.7

Phase

4

This medication works by blocking an enzyme that breaks down beneficial heart-protective peptides, allowing them to build up and reduce strain on the heart. It is used in combination with valsartan to treat heart failure with reduced ejection fraction, helping lower the risk of hospitalization and death.

Moleküler Ağırlık

411,5000 g/mol

LogP

3,70

TPSA

92,70 Å²

Lipinski RO5

Geçer

Terapötik Alanlar

Thyroid Cancer Cardiovascular Disease Systemic Lupus Erythematosus Chronic Kidney Disease Obesity Lymphoma Type 2 Diabetes Hypertension Breast Cancer HIV/AIDS Heart Failure Atrial Fibrillation

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Yapı

SVG PNG

Cite this structure

Embed this structure

SMILES

CCOC(=O)[C@H](C)C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)CCC(=O)O

InChI

InChI=1S/C24H29NO5/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28)/t17-,21+/m1/s1

Molecular Formula

C24H29NO5

HBD / HBA

2 / 5

Döndürülebilir Bağlar

12

Ağır Atomlar

30

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Sıkça Sorulan Sorular

This medication works by blocking an enzyme that breaks down beneficial heart-protective peptides, allowing them to build up and reduce strain on the heart. It is used in combination with valsartan to treat heart failure with reduced ejection fraction, helping lower the risk of hospitalization and death.

Yes, Sacubitril is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3137301. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 9811834. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Hızlı Veriler

Formül: C24H29NO5
Eş Anlamlılar: 3

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Tıbbi Sorumluluk Reddi

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.