Trimethobenzamide Hydrochloride

CHEMBL1200887 Phase 4 Onaylandı Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

424.9 g/mol

LogP

—

Phase

4

Trimethobenzamide hydrochloride is the hydrochloride salt of trimethobenzamide, an antiemetic that inhibits dopamine receptors in the medullary chemoreceptor trigger zone to control nausea and vomiting. It is available in oral and injectable formulations, commonly used for nausea relief in Parkinson's disease patients and postoperative settings. The hydrochloride salt enhances aqueous solubility for parenteral administration.

Moleküler Ağırlık

424,9000 g/mol

TPSA

69,30 Å²

Terapötik Alanlar

Parkinson's Disease

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Yapı

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SMILES

COc1cc(C(=O)NCc2ccc(OCCN(C)C)cc2)cc(OC)c1OC.Cl

InChI

InChI=1S/C21H28N2O5.ClH/c1-23(2)10-11-28-17-8-6-15(7-9-17)14-22-21(24)16-12-18(25-3)20(27-5)19(13-16)26-4;/h6-9,12-13H,10-11,14H2,1-5H3,(H,22,24);1H

Molecular Formula

C21H29ClN2O5

HBD / HBA

2 / 6

Döndürülebilir Bağlar

10

Ağır Atomlar

29

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Sıkça Sorulan Sorular

Trimethobenzamide hydrochloride is the hydrochloride salt of trimethobenzamide, an antiemetic that inhibits dopamine receptors in the medullary chemoreceptor trigger zone to control nausea and vomiting. It is available in oral and injectable formulations, commonly used for nausea relief in Parkinson's disease patients and postoperative settings. The hydrochloride salt enhances aqueous solubility for parenteral administration.

Yes, Trimethobenzamide Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200887. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 68385. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Hızlı Veriler

Formül: C21H29ClN2O5
Eş Anlamlılar: 1

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This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.