Trimipramine

CHEMBL644 Phase 4 Onaylandı Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

294.4 g/mol

LogP

5.8

Phase

4

Trimipramine is a tricyclic antidepressant (TCA) that inhibits reuptake of serotonin and norepinephrine while also possessing significant antihistaminic and anticholinergic properties, resulting in antidepressant and anxiolytic effects. It is used for major depressive disorder, generalized anxiety disorder, and has been investigated for schizophrenia due to its dopamine receptor affinity. Its strong sedative effects are attributed to H1 receptor blockade.

Moleküler Ağırlık

294,4000 g/mol

LogP

5,80

TPSA

6,50 Å²

Lipinski RO5

Geçer

Terapötik Alanlar

Schizophrenia Generalized Anxiety Disorder

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Yapı

SVG PNG

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SMILES

CC(CN(C)C)CN1c2ccccc2CCc2ccccc21

InChI

InChI=1S/C20H26N2/c1-16(14-21(2)3)15-22-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)22/h4-11,16H,12-15H2,1-3H3

Molecular Formula

C20H26N2

HBD / HBA

- / 2

Döndürülebilir Bağlar

4

Ağır Atomlar

22

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Sıkça Sorulan Sorular

Trimipramine is a tricyclic antidepressant (TCA) that inhibits reuptake of serotonin and norepinephrine while also possessing significant antihistaminic and anticholinergic properties, resulting in antidepressant and anxiolytic effects. It is used for major depressive disorder, generalized anxiety disorder, and has been investigated for schizophrenia due to its dopamine receptor affinity. Its strong sedative effects are attributed to H1 receptor blockade.

Yes, Trimipramine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL644. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 5584. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Hızlı Veriler

Formül: C20H26N2

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This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.