Vincamine
Vincamine is an indole alkaloid derived from the periwinkle plant Vinca minor that is a precursor to the synthetic derivative vinpocetine. It acts as a vasodilator and cerebral blood flow enhancer by inhibiting phosphodiesterase, reducing platelet aggregation, and relaxing vascular smooth muscle, thereby increasing oxygen and glucose delivery to brain tissue. It is used as a nootropic and circulatory supplement, primarily in Europe, for the treatment of cerebrovascular disorders, cognitive decline, and tinnitus.
Moleküler Ağırlık
354,4000 g/mol
LogP
2,90
TPSA
54,70 Ų
Lipinski RO5
Geçer
Pharmacokinetics (PK)
Pharmacodynamics (PD)
2D Yapı
Cite this structure
Embed this structure
SMILES
CC[C@]12CCCN3CCc4c(n(c5ccccc45)[C@@](O)(C(=O)OC)C1)[C@@H]32
InChI
InChI=1S/C21H26N2O3/c1-3-20-10-6-11-22-12-9-15-14-7-4-5-8-16(14)23(17(15)18(20)22)21(25,13-20)19(24)26-2/h4-5,7-8,18,25H,3,6,9-13H2,1-2H3/t18-,20+,21+/m1/s1
Molecular Formula
C21H26N2O3
HBD / HBA
1 / 4
Döndürülebilir Bağlar
3
Ağır Atomlar
26
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Sıkça Sorulan Sorular
Vincamine is an indole alkaloid derived from the periwinkle plant Vinca minor that is a precursor to the synthetic derivative vinpocetine. It acts as a vasodilator and cerebral blood flow enhancer by inhibiting phosphodiesterase, reducing platelet aggregation, and relaxing vascular smooth muscle, thereby increasing oxygen and glucose delivery to brain tissue. It is used as a nootropic and circulatory supplement, primarily in Europe, for the treatment of cerebrovascular disorders, cognitive decline, and tinnitus.
Yes, Vincamine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1165342. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 15376. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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