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Zilucoplan Sodium

CHEMBL5315048 Phase 4 Onaylandı Protein
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
3650.0 g/mol
LogP
—
Phase
4

Zilucoplan sodium is a macrocyclic peptide complement component 5 (C5) inhibitor that binds to the complement protein C5 and prevents its cleavage to C5a and C5b, blocking the terminal complement pathway and membrane attack complex formation. It is approved for subcutaneous self-administration in adults with generalized myasthenia gravis who are anti-acetylcholine receptor (AChR) antibody positive, preventing complement-mediated destruction of neuromuscular junction acetylcholine receptors. Its subcutaneous route and self-administration capability offer practical advantages over intravenous C5 inhibitors.

Moleküler Ağırlık

3650,0000 g/mol

TPSA

1090,00 Ų

Etki Mekanizması

As a monoclonal antibody, it binds with high specificity to its target antigen, modulating the immune response through mechanisms including receptor blockade, immune cell engagement, or targeted cytotoxicity.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mekanizma

As a monoclonal antibody, it binds with high specificity to its target antigen, modulating the immune response through mechanisms including receptor blockade, immune cell engagement, or targeted cytotoxicity.

SMILES

CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)NCCCC[C@@H](C(=O)[O-])NC(=O)[C@H](C1CCCCC1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](CCC(=O)[O-])NC(=O)[C@H](CC4=CNC5=C4C=CC=N5)NC(=O)[C@H](CC6=CC=C(C=C6)O)NC(=O)[C@H](C(C)(C)C)NC(=O)[C@H](CC(=O)[O-])N(C)C(=O)[C@@H]7CC(=O)NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N7)CC8=CC=CC=C8)CCCNC(=N)N)CCC(=O)[O-])C(C)C)NC(=O)C)C(=O)O.[Na+].[Na+].[Na+].[Na+]

InChI

InChI=1S/C172H278N24O55.4Na/c1-9-10-11-12-13-14-15-16-17-18-19-20-27-44-146(202)182-136(170(226)227)53-56-144(200)177-64-67-229-69-71-231-73-75-233-77-79-235-81-83-237-85-87-239-89-91-241-93-95-243-97-99-245-101-103-247-105-107-249-109-111-251-113-112-250-110-108-248-106-104-246-102-100-244-98-96-242-94-92-240-90-88-238-86-84-236-82-80-234-78-76-232-74-72-230-70-68-228-66-59-145(201)175-60-31-29-41-135(169(224)225)186-165(220)152(126-37-25-22-26-38-126)193-162(217)142-43-34-65-196(142)168(223)140(116-125-47-51-129(199)52-48-125)190-157(212)133(54-57-148(204)205)184-161(216)139(117-127-120-180-154-130(127)39-32-62-178-154)188-159(214)138(115-124-45-49-128(198)50-46-124)189-166(221)153(172(5,6)7)194-163(218)143(119-150(208)209)195(8)167(222)141-118-147(203)176-61-30-28-40-131(181-122(4)197)158(213)192-151(121(2)3)164(219)185-134(55-58-149(206)207)156(211)183-132(42-33-63-179-171(173)174)155(210)187-137(160(215)191-141)114-123-35-23-21-24-36-123;;;;/h21,23-24,32,35-36,39,45-52,62,120-121,126,131-143,151-153,198-199H,9-20,22,25-31,33-34,37-38,40-44,53-61,63-119H2,1-8H3,(H,175,201)(H,176,203)(H,177,200)(H,178,180)(H,181,197)(H,182,202)(H,183,211)(H,184,216)(H,185,219)(H,186,220)(H,187,210)(H,188,214)(H,189,221)(H,190,212)(H,191,215)(H,192,213)(H,193,217)(H,194,218)(H,204,205)(H,206,207)(H,208,209)(H,224,225)(H,226,227)(H4,173,174,179);;;;/q;4*+1/p-4/t131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,151-,152-,153+;;;;/m0..../s1

Molecular Formula

C172H274N24Na4O55

HBD / HBA

24 / 57

Döndürülebilir Bağlar

138

Ağır Atomlar

255

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Sıkça Sorulan Sorular

Zilucoplan sodium is a macrocyclic peptide complement component 5 (C5) inhibitor that binds to the complement protein C5 and prevents its cleavage to C5a and C5b, blocking the terminal complement pathway and membrane attack complex formation. It is approved for subcutaneous self-administration in adults with generalized myasthenia gravis who are anti-acetylcholine receptor (AChR) antibody positive, preventing complement-mediated destruction of neuromuscular junction acetylcholine receptors. Its subcutaneous route and self-administration capability offer practical advantages over intravenous C5 inhibitors.

As a monoclonal antibody, it binds with high specificity to its target antigen, modulating the immune response through mechanisms including receptor blockade, immune cell engagement, or targeted cytotoxicity.

Yes, Zilucoplan Sodium is an approved drug. It has reached clinical phase 4. It is classified as a Protein.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

  • ChEMBL — European Bioinformatics Institute (EBI). CHEMBL5315048. Open-access bioactivity database.
  • PubChem — National Center for Biotechnology Information (NCBI). CID 169490697. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

Tıbbi Sorumluluk Reddi

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.