Açıklama

Carvedilol increases digoxin plasma concentrations through P-gp inhibition and adds negative chronotropic and dromotropic effects, increasing the risk of bradycardia and AV block.

Mekanizma

Carvedilol is a P-gp inhibitor and reduces renal tubular digoxin secretion; combined beta-blockade and digoxin effects on AV node conduction are additive.

Klinik Önemi

Digoxin AUC may increase ~15–20%; symptomatic bradycardia and high-degree AV block have been reported.

Yönetim

Monitor heart rate and digoxin levels; check ECG periodically; reduce digoxin dose when carvedilol is initiated.

Tıbbi Sorumluluk Reddi

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.