Minor
Probable
Açıklama
Ranitidine can modestly increase diazepam bioavailability by raising gastric pH and weakly inhibiting hepatic CYP2C19-mediated diazepam metabolism.
Mekanizma
Ranitidine's H2 blockade raises intragastric pH, potentially improving diazepam dissolution and absorption; weak CYP2C19 inhibition further reduces N-desmethyldiazepam formation.
Klinik Önemi
Pharmacokinetic data demonstrate a modest (~25%) increase in diazepam AUC; additional sedation is possible but clinically minor in most patients.
Yönetim
No dose adjustment required; advise patients on additive sedation and to avoid alcohol; the interaction is less pronounced than with cimetidine.