Major
Established
Açıklama
Escitalopram and ondansetron together carry dual risks: serotonin syndrome and additive QT interval prolongation, making this combination particularly dangerous.
Mekanizma
Escitalopram inhibits SERT and prolongs the cardiac QT interval in a dose-dependent manner; ondansetron (5-HT3 antagonist) also prolongs QT and shares serotonergic receptor modulation.
Klinik Önemi
FDA issued a drug safety communication (2011) specifically warning against high-dose escitalopram + ondansetron due to fatal arrhythmia risk.
Yönetim
Avoid combining when possible; if essential, use the lowest effective doses, obtain baseline and follow-up ECGs, and correct electrolyte abnormalities.