Afatinib vs Digoxin

## Afatinib vs Digoxin: Overview

This comparison examines the pharmacological differences between **Afatinib** and **Digoxin**.

## Mechanism of Action

**Afatinib**: Irreversible covalent inhibitor of ErbB family (EGFR/HER1, HER2, HER4) tyrosine kinases.

**Digoxin**: Inhibits Na+/K+-ATPase, increasing intracellular calcium.

## Pharmacokinetics

**Half-life**: Afatinib — 37 hours; Digoxin — 36-48 hours.

## Chemical Properties

**Molecular Formula**: Afatinib — C24H25ClFN5O3; Digoxin — C41H64O14.

**Molecular Weight**: Afatinib — 485.9400 g/mol; Digoxin — 780.9430 g/mol.

**Type**: Afatinib — Small molecule; Digoxin — Small molecule.