Bupropion vs Sertraline

## Bupropion vs Sertraline: Overview

This comparison examines the pharmacological differences between **Bupropion** and **Sertraline**.

## Mechanism of Action

**Bupropion**: Norepinephrine-dopamine reuptake inhibitor (NDRI).

**Sertraline**: Selective serotonin reuptake inhibitor (SSRI).

## Pharmacokinetics

**Half-life**: Bupropion — 21 hours; Sertraline — 26 hours.

## Chemical Properties

**Molecular Formula**: Bupropion — C13H18ClNO; Sertraline — C17H17Cl2N.

**Molecular Weight**: Bupropion — 239.7420 g/mol; Sertraline — 306.2290 g/mol.

**Type**: Bupropion — Small molecule; Sertraline — Small molecule.