Doxycycline vs Tofacitinib

## Doxycycline vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Doxycycline** and **Tofacitinib**.

## Mechanism of Action

**Doxycycline**: Inhibits bacterial protein synthesis by binding 30S ribosomal subunit.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Doxycycline — 18-22 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Doxycycline — C22H24N2O8; Tofacitinib — C16H20N6O.

**Molecular Weight**: Doxycycline — 444.4350 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Doxycycline — Small molecule; Tofacitinib — Small molecule.