Erlotinib vs Tofacitinib

## Erlotinib vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Erlotinib** and **Tofacitinib**.

## Mechanism of Action

**Erlotinib**: Reversible inhibitor of EGFR (HER1) tyrosine kinase, blocking autophosphorylation.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Erlotinib — 36 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Erlotinib — C22H23N3O4; Tofacitinib — C16H20N6O.

**Molecular Weight**: Erlotinib — 393.4380 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Erlotinib — Small molecule; Tofacitinib — Small molecule.