Fentanyl vs Tofacitinib

## Fentanyl vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Fentanyl** and **Tofacitinib**.

## Mechanism of Action

**Fentanyl**: Highly potent synthetic mu-opioid receptor agonist approximately 100 times more potent than morphine.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Fentanyl — 2-4 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Fentanyl — C22H28N2O; Tofacitinib — C16H20N6O.

**Molecular Weight**: Fentanyl — 336.4700 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Fentanyl — Small molecule; Tofacitinib — Small molecule.