Fluconazole vs Sildenafil

## Fluconazole vs Sildenafil: Overview

This comparison examines the pharmacological differences between **Fluconazole** and **Sildenafil**.

## Mechanism of Action

**Fluconazole**: Inhibits fungal CYP51 (lanosterol 14-alpha-demethylase).

**Sildenafil**: Selective PDE5 inhibitor increasing cGMP.

## Pharmacokinetics

**Half-life**: Fluconazole — 30 hours; Sildenafil — 4 hours.

## Chemical Properties

**Molecular Formula**: Fluconazole — C13H12F2N6O; Sildenafil — C22H30N6O4S.

**Molecular Weight**: Fluconazole — 306.2710 g/mol; Sildenafil — 474.5800 g/mol.

**Type**: Fluconazole — Small molecule; Sildenafil — Small molecule.