Gefitinib vs Osimertinib

## Gefitinib vs Osimertinib: Overview

This comparison examines the pharmacological differences between **Gefitinib** and **Osimertinib**.

## Mechanism of Action

**Gefitinib**: Selective reversible inhibitor of EGFR tyrosine kinase.

**Osimertinib**: Third-generation irreversible EGFR TKI targeting T790M resistance mutation and activating mutations.

## Pharmacokinetics

**Half-life**: Gefitinib — 48 hours; Osimertinib — 48 hours.

## Chemical Properties

**Molecular Formula**: Gefitinib — C22H24ClFN4O3; Osimertinib — C28H33N7O2.

**Molecular Weight**: Gefitinib — 446.9000 g/mol; Osimertinib — 499.6050 g/mol.

**Type**: Gefitinib — Small molecule; Osimertinib — Small molecule.