Hydrochlorothiazide vs Paroxetine

## Hydrochlorothiazide vs Paroxetine: Overview

This comparison examines the pharmacological differences between **Hydrochlorothiazide** and **Paroxetine**.

## Mechanism of Action

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

**Paroxetine**: Potent selective serotonin reuptake inhibitor with additional muscarinic and NE reuptake inhibition.

## Pharmacokinetics

**Half-life**: Hydrochlorothiazide — 6-15 hours; Paroxetine — 21 hours.

## Chemical Properties

**Molecular Formula**: Hydrochlorothiazide — C7H8ClN3O4S2; Paroxetine — C19H20FNO3.

**Molecular Weight**: Hydrochlorothiazide — 297.7400 g/mol; Paroxetine — 329.3730 g/mol.

**Type**: Hydrochlorothiazide — Small molecule; Paroxetine — Small molecule.