Hydrochlorothiazide vs Rabeprazole

## Hydrochlorothiazide vs Rabeprazole: Overview

This comparison examines the pharmacological differences between **Hydrochlorothiazide** and **Rabeprazole**.

## Mechanism of Action

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

**Rabeprazole**: Proton pump inhibitor irreversibly inhibiting gastric H+/K+-ATPase with faster onset than omeprazole.

## Pharmacokinetics

**Half-life**: Hydrochlorothiazide — 6-15 hours; Rabeprazole — 1-2 hours.

## Chemical Properties

**Molecular Formula**: Hydrochlorothiazide — C7H8ClN3O4S2; Rabeprazole — C18H21N3O3S.

**Molecular Weight**: Hydrochlorothiazide — 297.7400 g/mol; Rabeprazole — 359.4440 g/mol.

**Type**: Hydrochlorothiazide — Small molecule; Rabeprazole — Small molecule.