Hydrochlorothiazide vs Sitagliptin

## Hydrochlorothiazide vs Sitagliptin: Overview

This comparison examines the pharmacological differences between **Hydrochlorothiazide** and **Sitagliptin**.

## Mechanism of Action

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

**Sitagliptin**: DPP-4 inhibitor increasing incretin levels.

## Pharmacokinetics

**Half-life**: Hydrochlorothiazide — 6-15 hours; Sitagliptin — 12.4 hours.

## Chemical Properties

**Molecular Formula**: Hydrochlorothiazide — C7H8ClN3O4S2; Sitagliptin — C16H15F6N5O.

**Molecular Weight**: Hydrochlorothiazide — 297.7400 g/mol; Sitagliptin — 407.3140 g/mol.

**Type**: Hydrochlorothiazide — Small molecule; Sitagliptin — Small molecule.