Hydrochlorothiazide vs Telmisartan

## Hydrochlorothiazide vs Telmisartan: Overview

This comparison examines the pharmacological differences between **Hydrochlorothiazide** and **Telmisartan**.

## Mechanism of Action

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

**Telmisartan**: Selective angiotensin II type 1 receptor antagonist; also a partial PPAR-gamma agonist.

## Pharmacokinetics

**Half-life**: Hydrochlorothiazide — 6-15 hours; Telmisartan — 24 hours.

## Chemical Properties

**Molecular Formula**: Hydrochlorothiazide — C7H8ClN3O4S2; Telmisartan — C33H30N4O2.

**Molecular Weight**: Hydrochlorothiazide — 297.7400 g/mol; Telmisartan — 514.6230 g/mol.

**Type**: Hydrochlorothiazide — Small molecule; Telmisartan — Small molecule.