Methotrexate vs Prednisone

## Methotrexate vs Prednisone: Overview

This comparison examines the pharmacological differences between **Methotrexate** and **Prednisone**.

## Mechanism of Action

**Methotrexate**: Dihydrofolate reductase inhibitor.

**Prednisone**: Synthetic corticosteroid; suppresses inflammation via glucocorticoid receptor.

## Pharmacokinetics

**Half-life**: Methotrexate — 3-10 hours; Prednisone — 2-3 hours.

## Chemical Properties

**Molecular Formula**: Methotrexate — C20H22N8O5; Prednisone — C21H26O5.

**Molecular Weight**: Methotrexate — 454.4400 g/mol; Prednisone — 358.4280 g/mol.

**Type**: Methotrexate — Small molecule; Prednisone — Small molecule.