Methotrexate vs Tacrolimus

## Methotrexate vs Tacrolimus: Overview

This comparison examines the pharmacological differences between **Methotrexate** and **Tacrolimus**.

## Mechanism of Action

**Methotrexate**: Dihydrofolate reductase inhibitor.

**Tacrolimus**: Calcineurin inhibitor binding FKBP12; suppresses IL-2 transcription.

## Pharmacokinetics

**Half-life**: Methotrexate — 3-10 hours; Tacrolimus — 12 hours.

## Chemical Properties

**Molecular Formula**: Methotrexate — C20H22N8O5; Tacrolimus — C44H69NO12.

**Molecular Weight**: Methotrexate — 454.4400 g/mol; Tacrolimus — 804.0180 g/mol.

**Type**: Methotrexate — Small molecule; Tacrolimus — Small molecule.