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Acetohydroxamic Acid

CHEMBL734 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
75.1 g/mol
LogP
-1.6
Phase
4

A medication used to treat chronic urinary tract infections caused by bacteria that produce urease, an enzyme that breaks down urea and makes the urine alkaline, allowing kidney stones to form. By blocking urease, it prevents the bacteria from creating the alkaline environment they need to thrive and reduces the growth of certain types of kidney stones. It is typically used as a complement to antibiotics, not as a replacement, and requires monitoring for side effects including tremors and anemia.

分子量

75.0700 g/mol

LogP

-1.60

TPSA

49.30 Ų

Lipinski 五规则

符合

治疗领域

Tuberculosis

作用机制

Inhibits bacterial urease, the enzyme that hydrolyzes urea to ammonia and carbon dioxide, reducing the alkalinization of urine that promotes stone formation and infection persistence.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

机制

Inhibits bacterial urease, the enzyme that hydrolyzes urea to ammonia and carbon dioxide, reducing the alkalinization of urine that promotes stone formation and infection persistence.

二维结构

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC(=O)NO

                

                

                
                

                    
InChI

                    
InChI=1S/C2H5NO2/c1-2(4)3-5/h5H,1H3,(H,3,4)

                

                

                

                    
                    

                        
Molecular Formula

                        
C2H5NO2

                    

                    
                    

                        
HBD / HBA

                        
2 / 2

                    

                    
                    

                        
可旋转键数

                        
0

                    

                    
                    
                    

                        
重原子数

                        
5

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
A medication used to treat chronic urinary tract infections caused by bacteria that produce urease, an enzyme that breaks down urea and makes the urine alkaline, allowing kidney stones to form. By blocking urease, it prevents the bacteria from creating the alkaline environment they need to thrive and reduces the growth of certain types of kidney stones. It is typically used as a complement to antibiotics, not as a replacement, and requires monitoring for side effects including tremors and anemia.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits bacterial urease, the enzyme that hydrolyzes urea to ammonia and carbon dioxide, reducing the alkalinization of urine that promotes stone formation and infection persistence.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Acetohydroxamic Acid is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL734.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 1990.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.