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Afamelanotide

CHEMBL441738 Phase 4 已批准 Protein
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
1646.8 g/mol
LogP
-3.5
Phase
4

A synthetic version of a naturally occurring hormone that stimulates melanin production in the skin, increasing the skin's natural protective pigmentation. It has been studied for its potential to protect certain patients from severe light-induced reactions and has also been investigated for effects on blood vessel health.

分子量

1646.8000 g/mol

LogP

-3.50

TPSA

643.00 Ų

Lipinski 五规则

不符合

治疗领域

Stroke

作用机制

Stimulates melanocyte proliferation and melanin synthesis, increasing photoprotective pigmentation in the skin.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

机制

Stimulates melanocyte proliferation and melanin synthesis, increasing photoprotective pigmentation in the skin.

二维结构

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(N)=O)C(C)C

                

                

                
                

                    
InChI

                    
InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C78H111N21O19

                    

                    
                    

                        
HBD / HBA

                        
23 / 22

                    

                    
                    

                        
可旋转键数

                        
51

                    

                    
                    
                    

                        
重原子数

                        
118

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
A synthetic version of a naturally occurring hormone that stimulates melanin production in the skin, increasing the skin's natural protective pigmentation. It has been studied for its potential to protect certain patients from severe light-induced reactions and has also been investigated for effects on blood vessel health.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Stimulates melanocyte proliferation and melanin synthesis, increasing photoprotective pigmentation in the skin.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Afamelanotide is an approved drug. It has reached clinical phase 4. It is classified as a Protein.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL441738.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 16197727.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.